Nonreciprocal Wavefront Engineering with Time-Modulated Gradient Metasurfaces

We propose a paradigm to realize nonreciprocal wavefront engineering using time-modulated gradient metasurfaces. The essential building block of these surfaces is a subwavelength unit cell whose reflection coefficient oscillates at low frequency. We demonstrate theoretically and experimentally that such modulation permits tailoring the phase and amplitude of any desired nonlinear harmonic and determines the behavior of all other emerging fields. By appropriately adjusting the phase delay applied to the modulation of each unit cell, we realize time-modulated gradient metasurfaces that provide efficient conversion between two desired frequencies and enable nonreciprocity by (i) imposing drastically different phase gradients during the up/down conversion processes and (ii) exploiting the interplay between the generation of certain nonlinear surface and propagative waves. To demonstrate the performance and broad reach of the proposed platform, we design and analyze metasurfaces able to implement various functionalities, including beam steering and focusing, while exhibiting strong and angle-insensitive nonreciprocal responses. Our findings open an alternative direction in the field of gradient metasurfaces, in which wavefront control and magnetic-free nonreciprocity are locally merged to manipulate the scattered fields

ECoFFeS: A Software Using Evolutionary Computation for Feature Selection in Drug Discovery

Feature selection is of particular importance in the field of drug discovery. Many methods have been put forward for feature selection during recent decades. Among them, evolutionary computation has gained increasing attention owing to its superior global search ability. However, there still lacks a simple and efficient software for drug developers to take advantage of evolutionary computation for feature selection. To remedy this issue, in this paper, a user-friendly and standalone software, named ECoFFeS, is developed. ECoFFeS is expected to lower the entry barrier for drug developers to deal with feature selection problems at hand by using evolutionary algorithms. To the best of our knowledge, it is the first software integrating a set of evolutionary algorithms (including two modified evolutionary algorithms proposed by the authors) with various evaluation combinations for feature selection. Specifically, ECoFFeS considers both single-objective and multi-objective evolutionary algorithms, and both regression- and classification-based models to meet different requirements. Five data sets in drug discovery are collected in ECoFFeS. In addition, to reduce the total analysis time, the parallel execution technique is incorporated into ECoFFeS. The source code of ECoFFeS can be available from https://github.com/JiaweiHuang/ECoFFeS/

Momentum and market correlation

This paper proposes that an important source of momentum profits is market information associated with correlation to general market movements. Empirical tests for U.S. stocks in the sample period 1965 to 2013 indicate that most momentum profits can be attributed to the correlation of big- and medium-capitalization stocks with the CRSP market index. Further results show that small loser stocks have low correlation to the market and post-formation return reversal, small losers can be added to long winner portfolios to enhance profits, and momentum crashes can be reduced by suspending portfolio formation in bear markets. We conclude that momentum profits are related to market information and therefore not entirely anomalous as commonly believed

The structure and evolution of trade relations between countries along the Belt and Road

Trade facilitation is one of the five main agendas of the Belt and Road Initiative (BRI). Social network analysis has helped understand the complexity of trade networks, but existing studies tend to overlook the fact that not all bilateral trade relations are equally important to a country. To fill this gap in the literature, this paper focuses on the top 2 trade relations networks to illuminate the structure and evolution of B&R trade relations, the relative positions of different countries, and changes in the composition of trade communities (e.g., the community leaders) and the changing patterns of trade between them. We find rich dynamics over time both inter- and intra-communities. The overall international trade networks of B&R countries experienced a leadership change from Russia to China on one hand, some temporary communities experienced emergence, disappearance (e.g. the Kuwait- and Thailand-led communities) or reemergence (e.g. Poland-led community), and a community membership was generally consistent on the other hand. Since the future impacts of China’s BRI will depend on the degree of integration of the connected regions, some countries with stable and high centrality indices (e.g. Russia, Singapore, Serbia, Greece, Turkey, Iran, Poland, Hungary and Romania) could be selected by China as strategic regional partners, and countries with a strategically important geographical position but weak trade links (e.g. Myanmar, Pakistan, and Belarus) should be prioritized

Digenean parasites of Chinese marine fishes: a list of species, hosts and geographical distribution

In the literature, 630 species of Digenea (Trematoda) have been reported from Chinese marine fishes. These belong to 209 genera and 35 families. The names of these species, along with their hosts, geographical distribution and records, are listed in this paper

Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation.

Nipah virus is an emergent paramyxovirus that causes deadly encephalitis and respiratory infections in humans. Two glycoproteins coordinate the infection of host cells, an attachment protein (G), which binds to cell surface receptors, and a fusion (F) protein, which carries out the process of virus-cell membrane fusion. The G protein binds to ephrin B2/3 receptors, inducing G conformational changes that trigger F protein refolding. Using an optical approach based on second harmonic generation, we show that monomeric and dimeric receptors activate distinct conformational changes in G. The monomeric receptor-induced changes are not detected by conformation-sensitive monoclonal antibodies or through electron microscopy analysis of G:ephrinB2 complexes. However, hydrogen/deuterium exchange experiments confirm the second harmonic generation observations and reveal allosteric changes in the G receptor binding and F-activating stalk domains, providing insights into the pathway of receptor-activated virus entry.Nipah virus causes encephalitis in humans. Here the authors use a multidisciplinary approach to study the binding of the viral attachment protein G to its host receptor ephrinB2 and show that monomeric and dimeric receptors activate distinct conformational changes in G and discuss implications for receptor-activated virus entry

Evolution of superconductivity in K2-xFe4+ySe5: Spectroscopic studies of X-ray absorption and emission.

This study investigates the evolution of superconductivity in K2-xFe4+ySe5 using temperature-dependent X-ray absorption and resonant inelastic X-ray scattering techniques. Magnetization measurements show that polycrystalline superconducting (SC) K1.9Fe4.2Se5 has a critical temperature (T c) of ∼31 K with a varying superconducting volume fraction, which strongly depends on its synthesis temperature. An increase in Fe-structural/vacancy disorder in SC samples with more Fe atoms occupying vacant 4d sites is found to be closely related to the decrease in the spin magnetic moment of Fe. Moreover, the nearest-neighbor Fe-Se bond length in SC samples exceeds that in the non-SC (NS) sample, K2Fe4Se5, which indicates a weaker hybridization between the Fe 3d and Se 4p states in SC samples. These results clearly demonstrate the correlations among the local electronic and atomic structures and the magnetic properties of K2-xFe4+ySe5 superconductors, providing deeper insight into the electron pairing mechanisms of superconductivity